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Histopathological changes and changes in nuclear DNA content were studied in 30 rectal mucosal specimens taken from 19 patients with ulcerative colitis and 12 specimens taken from 12 control subjects.<BR>No cytological or structural abnormalities were found in 13 specimens taken from 9 patients with inactive colitis, while 11 out of 17 specimens taken from 13 patients with active colitis showed cytological and/or structural abnormalities. Although these changes were evaluated as "negative for dysplasia", one was assessed as "indefinite for dysplasia".<BR>There was an increase of cellular DNA content in the rectal mucosa of patients with ulcerative colitis. The difference was significant between patients with inactive colitis and controls, but not significant between patients with active colitis and controls. Patients with longstanding colitis also showed a significant increase of cellular DNA content. The population of S, G<SUB>2</SUB>+M cells in the luminal surface of the crypt was significantly increased in the rectal mucosa of patients with inactive colitis and/or patients with long-standing disease.<BR>Thus, the present studies disclosed that there were significant increases in proliferative activity and the proliferative zone in the rectal mucosa of patients with inactive and/or longstanding colitis, despite a lack of histopathologically evident dysplasia.
- 日本大腸肛門病学会の論文
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