I. A Study of Adjuvant Chemotherapy at Time of Operation for Colon Cancer, Especially Subserosal Administration Method

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This paper is to study the method to ensure the sufficient high concentration of carcinostatics (Mitomycin-C) to the portal vein, lymphatic duet and lymphnode.<BR>In this study, 37 dogs were used as experiments and 10 patients of colon cancer were studied clinically. MMC solution were infused into the subserosa, colonic artery, inferior vein, lumen of colon and abdominal cavity respectively. In each group, the concentration of MMC in the vein, portal vein and thoratic duct were measured. In clinical cases, the concentration of MMC in lymphnodes were measured.<BR>Result : 1) Subserosal administration of MMC gave the most high concentration in the thoratic duct. 2) MMC concentration in the portal vein has no signifficant difference in any four procedures of administration except for the intraluminal administration group. 3) Between metastatic and non metastatic lymphnode, there were signifficant differences in concentration of MMC.<BR>Thse results suggested that the intra-subserosal administration of MMC at time of surgery is the most effective method to treat cancer cells in the colonic lymphatic system.<BR>This method will be also useful to treat cancer cells in the portal vein and anastomosis site.
日本大腸肛門病学会の論文