II. Experimental aud Clinical Study of Cryonecrosis Applied for Treatmeut of Hemorrhoids

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The fundomental experimental study was performed to apply cryotherapy to the hemorrhoid. On the liver of rabbit, the cryonecrosis was made by the two, cycle freezing with liquid nitrogen. By the hystologic and cystologic investigation, it was proved that the cryonecrosis was induced by cell injury and vascular stasis. This necrosis have never spreaded beyond the frozen area. This characteristics seems to be favourable for necrotherapy of hemorrhoid considering the essential quality of hemorrhoid. In the clinical studies, the temperature change during freezing and thawing were measured to classify the cryo-resistence of hemorrhoidal tissue. The liquid-nitrogen groop revealed the 40°-100°C/minit freezing velosity and 4°-9°C/ minit, thawing velosity which were mostly beneficial for cryonecrosis confirmed by histological studies. On the other hand, the rapid freezing and slow thawing were not obtained in the CO2 groop suspecting the necessity of the longer freezing time for complete necrosis. In both groop, the sphincter muscle have never affected by freezing. The sever unfavourable complication have never occured in all the clinical cases.
日本大腸肛門病学会の論文