II. The Effect of Betamethasone Suppositories in Ulcerative Colitis

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Fourteen patients (9 patients with proctitis, 5 with proctosigmoid, left-sided or total colitis) were treated with betamethasone suppositories. Eleven patients were into remission but 3 patients had not responded favourably.<BR>Side-effects were not observed in all cases.<BR>Maximum plasma betamethasone level (4.15±0.21ng/ml) was seen 5 hours after insert-ing 1 mg of betamethasone suppository. It was about a third of maximum plasma level after oral administration of same dose of betamethasone.<BR>Betamethasone suppositories are effective and useful agents for the treatment of proctitis and colitis of which lesion is limited in distal segment of the large intestine.
日本大腸肛門病学会の論文