1. Electron Microscopic Studies on the Epithelium of Human Anal Sinus
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概要
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The structural organization of the epithelium at the middle part of human anal sinus was studied with electron microscope. The observed area is the portion covered by the stratified squamouns epithelium, stratified cuboidal or columnar epithelium, simple cuboidal epithelium and pseudostratified columnar epithelium.<BR>In the region covered by stratified squanous epithelium, the epithelial cells are similar to the cells of the transitional skin in human anal canal, but its cytoplasm contain well developed organelles. Especially glycogen granules and Odland bodies appear in the cells of granular layer and the upper part of spinous layer. In granular layer, two kinds of keratohyalin granules, round and irregular, are observed. In the surface layer, keratinization does not always progress uniformly.<BR>In the regions devoid of stratified squamous epithelium, most of differentiated cells contain a variable number of secretory granules in the supranuclear portion, but basal cells and some of cells in the surface layer do not have such granules. Their granules are considered to be produced from Golgi apparatus and they contain PAS-positive material. Of free surface of the cells in these area, there are found a few irregula short microvilli. They are coveredd filamentous or particular surface coat.<BR>Endocrine cells are generally columar in shape and are scattered among the other epithelial cells. These are usually in direct contact with the basement membrane and the apex of cells almost do not reach to the free border. Endocrine cells appear in the region devoid of stratified squamous epithelium and they have no relation to the crypt or gland. Abundant round granules with variable electron density, measuring about 130-150 mμ in dia-meter, are located in the infranuclear portion of the cell.<BR>Wandering cells are found among the epithelial cells in the observed area.
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