2. Ultrastructure of Carcinoid Tumors in Several Organs

概要

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Electron microscopic analysis of paranasal, bronchial, gastric, appendiceal and rectal carcinods indicated that tumor cells of all cases contained specific endocrine type secretory granules and showed either the presence of absence of acinar or tubular differentiation.<BR>Besides the pleomorphism of appendiceal carcinoid granules, the size of spherical secretory granules in other cases varied to the limited extent from one case to another and from one cell to another. While EM survey is one of the most useful tool for the diagnostic confirmation of carcinoid tumor, combined inmunohistochemical, endocinological and boichemical examinations of boigenic substances such as amines and polypeptide hormones may be essential for the elucidation of functional and histogenetic aspects of this tumor type. The new concept of carcinoid as tumor of neural crest origin may not be in accordance with some findings of reported cases.
日本大腸肛門病学会の論文