Fatal Aplastic Anemia Caused by Epstein-Barr Virus Infection after Autologous Bone Marrow Transplantation for Non-Hodgkin Malignant Lymphoma
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概要
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We report a case of severe and fatal aplastic anemia during an episode of infectious mononucleosis caused by Epstein-Barr (EB) virus infection. The 13-year-old female patient had shown normal hematological findings and had previously undergone repeated chemotherapy and autologous bone marrow transplantation for refractory non-Hodgkin malignant lymphoma (NHL). She was probably in an immuno-suppressed condition prior to this episode of infection. The possible causal relationship of the EB virus infection in the pathogenesis of aplastic anemia was documented by the clinical course, demonstration of EB virus genome in the bone marrow cells, and an elevated plasma interferon (IFN)-γlevel.(Internal Medicine 33: 303-307, 1994)
著者
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SHINOHARA Kenji
the Division of Hematology, Department of Medicine and Department of Patholgoy, Yamaguchi Prefecture
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NOMIYAMA Jun
The Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital
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SHINOHARA Kenji
The Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital
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INOUE Hirofumi
The Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital
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OEDA Eiichi
The Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital
関連論文
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- Fatal Aplastic Anemia Caused by Epstein-Barr Virus Infection after Autologous Bone Marrow Transplantation for Non-Hodgkin Malignant Lymphoma
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