Temporal Alterations of Immunohistochemical Findings in Polymyositis.
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the pathological mechanisms of polymyositis, we performed immunohistochemical analyses with biopsied muscles. Comparative studies using specimens obtained from the same patient enabled us to analyze the pathological alterations at different sequential clinical phases without taking into account each immunogenetic difference. Expression of MHC (major histocompatibility complex) antigens, especially ectopic MHC-class-II antigens, in muscle fibers and infiltrating T-cells were shown to increase concomitantly with the clinically observed exacerbation. Moreover, other observations seem to support the possibilities that 1) administration of steroids lowers the number of invading CDS-positive cells, 2) induction of MHC-class-I antigens in muscle fibers precedes the inflammatory cell infiltration and that 3) remaining MHC-class-I antigens in muscle fibers may explain the recurrence of myositis often observed in the follow up period.(Internal Medicine 33: 263-270, 1994)
- 社団法人 日本内科学会の論文
著者
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MORIWAKA Fumio
the Department of Neurology, Hokkaido University School of Medicine
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Tashiro Kunio
The Department Of Neurology Hokkaido University Graduate School Of Medicine
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Tajima Yasutaka
The Department Of Neurology Kushiro Rosai Hospital
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MORIWAKA Fumio
the Department of Neurology, Hokkaido University Hospital
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