Acquired Amegakaryocytic Thrombocytopenic Purpura with Humoral Inhibitory Factor for Megakaryocyte Colony Formation.
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概要
- 論文の詳細を見る
A 67-year-old man with thrombocytopenia, and amegakaryocytic but otherwise normal bone marrow, was evaluated. Antibody against thrombocytes was negative and the half-life of thrombocytes was normal. In vitro clonal culture of the patient's bone marrow cells yielded no megakaryocyte colony with normal granulocyte-macrophage and erythroid colony formation. Megakaryocyte colony formation of the control bone marrow cells was significantly suppressed by the addition of the patient's serum to the culture, suggesting the existence of humoral inhibitory factor(s) for megakaryocyte colony formation. Therapeutic trials with plasma exchange, cyclosporine, prednisolone, and cyclosporine plus prednisolone were all unsuccessful, but serious bleeding has been absent.(Internal Medicine 33:147-149, 1994)
- 社団法人 日本内科学会の論文
著者
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SAITO Hiroshi
the Department of Internal Medicine, Nagano Red Cross Hospital
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HIRAMATSU Kunihide
the Department of Aging Medicine and Geriatrics
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AIZAWA Toru
the Department of Geriatrics, Endocrinology and Metabolism, School of Medicine, Shinshu University
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YAMADA Takashi
the Department of Medicine, Kashiwa City Hospital
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Hashizume Kiyoshi
The Department Of Aging Medicine And Geriatrics
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OHARA Noriko
the Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
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HASHIZUME Kiyoshi
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
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KATAI Miyuki
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
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KITANO Kiyoshi
The Department of Second Internal Medicine, Shinshu University School of Medicine
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SHINODA Toshio
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
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WAKATA Shunji
Wakata Clinic
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NAKAHATA Tatsutoshi
The Department of Pediatrics, Shinshu University School of Medicine
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HIRAMATSU Kunihide
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
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