Heart Type Fatty Acid Binding Protein Is More Sensitive Than Troponin I and Creatine Kinase Myocardial Band at Early Stage in Determining Myocardial Injury Caused by Percutaneous Coronary Intervention

概要

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Measurement of circulating cardiac biomarkers has enabled early diagnosis and risk assessment of acute coronary syndrome. Heart type fatty acid binding protein (H-FABP) is a relatively novel marker for the diagnosis of myocardial injury. The purpose of the present study was to compare H-FABP with Troponin I (cTnI) and creatine kinase myocardial band (CK-MB) in determining myocardial injury in patients with early stage of percutaneous coronary intervention (PCI). Blood was withdrawn one hour before and 3 hours after PCI from 40 patients to measure H-FABP, cTnI and CKMB. H-FABP was measured qualitatively. CK-MB and cTnI were measured by a sandwich enzyme-linked immunosorbent assay. Before PCI, H-FABP was found to be negative, while cTnI and CK-MB were found to be in normal ranges. Statistical analysis of measurements 3 hours after PCI revealed that H-FABP was significantly positive in 15 (37%) patients, while cTnI was elevated in 11 (27%) patients and CKMB was elevated in 8 (20%) patients. H-FABP is statistically more sensitive than cTnI and CK-MB at detecting myocardial injury after PCI.H-FABP can be used in early stages to detect myocardial injury caused by PCI. H-FABP is more sensitive than cTnI and CK-MB in determining myocardial injury due to PCI within 3 hours. H-FABP may help us stratify a patient’s risk in early stages after PCI.