Synthesis and Pharmacology of Some Bis-quaternary Salts of the Bicyclo (2. 2. 2) octane Series, Including 2-(3-Dimethylaminopropyl)-3a, 4, 7, 7a-tetrahydroisoindoline Dimethiodide (KK-25-S):A New Hypotensive

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概要

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• (1) A series of some bis-quaternary salts containing the bicyclo (2. 2. 2)-octane ring has been found to possess hypotensive effect. The relationship between chemical structure and hypotensive effect of these compounds was investigated.(2) 2-(3-Dimethylaminopropyl)-3a, 4, 7, 7a-tetrahydroisoindoline dime-thiodide (KK-25-S) has been found to be the appropriate one as a hypotensive agent of this series.(3) KK-25-S shows specific ganglionic blocking action with a long duration of action.(4) After oral administration, KK-25-S is relatively well absorbed.(5) No evidence of chronic toxicity was observed in dogs and monkeys after the oral administration of 5mg./Kg. for a period of 90 days.

• International Heart Journal刊行会の論文

著者

• Ikeda Tetsutaro

  Faculty Of Pharmacy Kanazawa University

• KIDO Ryonosuke

  Research Laboratory, Shionogi & Co., Ltd.

• KITAHONOKI Keizo

  Research Laboratory, Shionogi & Co., Ltd.

• MINESHITA Tetsuo

  Research Laboratory, Shionogi & Co., Ltd.

• KITAHONOKI Keizo

  Research Laboratory, Shionogi & Co., Ltd.

• MINESHITA Tetsuo

  Research Laboratory, Shionogi & Co., Ltd.

• IKEDA Tetsutaro

  Faculty of Pharmaceutical Sciences, Chemical Department, University of Kanazawa

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• Synthesis and Pharmacology of Some Bis-quaternary Salts of the Bicyclo (2. 2. 2) octane Series, Including 2-(3-Dimethylaminopropyl)-3a, 4, 7, 7a-tetrahydroisoindoline Dimethiodide (KK-25-S):A New Hypotensive

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