Phentolamine:Use in Congestive Heart Failure

概要

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Two patients (group 1) with relatively normal left ventricles who had never been in left ventricular failure, and 4 patients (group 2) with abnormal left ventricles who had previously been in left ventricular failure, underwent right and left heart catheterization. Cardiac pressures and cardiac output were measured before and at various time intervals during the continuous administration of 0.3mg. per min. of phentolamine.Among the subjects in group 1, phentolamine produced only minimal changes in the measured hemodynamic parameters. Among the subjects in group 2, phentolamine produced marked increases in the cardiac index and stroke index. A striking fall in the pulmonary artery pressure and left ventricular end-diastolic pressure was also observed.Phentolamine is ideally suited for the treatment of patients in left ventricular failure. It is very effective, rapid in action, devoid of side effects and produces no arrhythmias.
International Heart Journal刊行会の論文