The Effects of Chlorpromazine on the Electrical and Mechanical Activities of the Isolated Guinea Pig Heart
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概要
- 論文の詳細を見る
(1) The effects of chlorpromazine (CP) on the action potentials (AP's) and contractions of the isolated guinea pig heart were investigated by means of a microelectrode and a strain gauge transducer.(2) CP at concentrations of 2×10-6 to 5×10-1Gm./ml. decreased markedly the pacemaker activity of the sino-atrial node. By the repeated application of the drug to the tissue, however, a considerable tolerance to the drug was developed, and in some preparations the acceleration of the beat rate occurred rather than the deceleration.(3) CP shortened AP-duration of the left atrial muscle and the left ventricular papillary muscle by 10 to 20%, but slight prolongation occurred for a longer treatment with the drug in some preparations.(4) CP definitely decreased the maximum rate of rise of AP's of both atrial and ventricular muscles without significant change in the resting potential.(5) The excitability assumed by the strength-duration curve of the atrium was decreased by the application of CP, and the full-recovery time of the atrium was delayed.(6) Contractile tension of both the atrium and the ventricle was strikingly reduced by the application of CP, but recovery was almost complete.(7) Clinical electrocardiographic abnormalities induced by fairly high dosage of the phenothiazine drugs and antiarrhythmic actions of these drugs were discussed in relation to the results obtained.
- International Heart Journal刊行会の論文
著者
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Imanishi Sunao
Department Of Physiology And Surgery Medical College Of Oita
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ARITA Makoto
First Department of Internal Medicine Faculty of Medicine, Kyushu University
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IMANISHI Sunao
Department of Physiology, Faculty of Medicine, Kyushu University
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