Left Ventricular Function in Experimental Pulmonary Embolism

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The hemodynamic effects of acute pulmonary embolism were studied in 13 pentobarbital-anesthetized dogs (19.1 to 27.2Kg). Pulmonary embolism was produced by injections of 1-8ml. of a 33% barium sulfate emulsion into the right ventricle. Observations were made before and 10-15min. after each of several injections. Cardiac output, stroke volume, left ventricular systolic pressure, aortic mean pressure, left ventricular ejection fraction, and left ventricular end-diastolic volume fell following repeated pulmonary embolization. Left ventricular end-diastolic pressure did not change significantly; thus, left ventricular end-diastolic distensi-bility diminished. Peak circumferential-shortening rate of the left ventricle normalized as rate per unit length of circumference remained unchanged in spite of a decrease in developed force. Left ventricular stroke work for any given end-diastolic volume in each animal following pulmonary embolization fell below the regression line for the control state. We conclude that repeated acute pulmonary embolization impairs left ventricular contractility.
International Heart Journal刊行会の論文