21-Hydroxylase Deficiency Associated with Male Infertility: Report of 2 Cases with Gene Analyses

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概要

• 論文の詳細を見る

• We treated two patients with male infertility due to 21-hydroxylase deficiency. Endocrinologic examinations disclosed low levels of LH and FSH, with elevated ACTH and 17-OH-progesterone in both. In addition, a small testicular tumor was found in Case 1, which disappeared after adrenal replacement. Suppressed gonadotropin levels caused by increased androgen seemed to underlie the sperm dysfunction in these patients. Dexamethasone and then clomiphene were administered in Case 1, and dexamethasone in Case 2. Spermatogenesis was somewhat improved in both patients and pregnancy achieved in Case 2, though spontaneous abortion later occurred.

著者

• Moriwaki Yuji

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Japan

• Sumida Chihiro

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Japan

• Tsutsumi Zenta

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Japan

• Kurajoh Masafumi

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Japan

• Kondoh Nobuyuki

  Department of Urology, Hyogo College of Medicine, Japan

関連論文

• 21-Hydroxylase Deficiency Associated with Male Infertility: Report of 2 Cases with Gene Analyses

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