A Case of Primary Intrahepatic Sclerosing Cholangitis(PISC) Complicated with Atypical Biliary Epithelial Proliferation.
スポンサーリンク
概要
- 論文の詳細を見る
A 70-yr-old woman was admitted to our hospital with duodenal ulcer and anemia. The result of liver function test was abnormal and showed persistent elevated alkaline phosphatase levels. Thus, after recovery from duodenal ulcer, endoscopic retrograde cholangiopancreatography (ERCP) was performed ; the characteristic "beaded" appearance with band-like strictures and saccular outpouchings affecting the intrahepatic biliary system were found. The diagnosis of primary intrahepatic sclerosing cholangitis (PISC) was made on the basis of the generally accepted diagnostic criteria of primary sclerosing cholangitis (PSC). However, the histological finding from a liver biopsy specimen revealed highly atypical epithelial proliferation of bile ducts. This case of PISC complicated with atypical biliary glandular changes is described, and the distinction between PISC and carcinoma of the bile duct is discussed.(Internal Medicine 31 : 114-121, 1992)
- 社団法人 日本内科学会の論文
著者
-
Aizawa Kenichi
Department of Cardiology, Tokyo University
-
Kawaguchi Shinya
Department Of Surgery Iwaki-kyoritsu Hospital
-
Nishioka Shingo
The Second Department Of Internal Medicine Wakayama Medical College
-
ITOH Hidekazu
the Secound Department of Internal Medicine, Wakayama Medical College
-
KAWAGUCHI Shinya
Departments of Internal Medicine, Hashimoto Municipal Hospital
-
DOI Misako
Departments of Internal Medicine, Hashimoto Municipal Hospital
-
MIZUNO Wakako
Departments of Internal Medicine, Hashimoto Municipal Hospital
-
URAGAMI Kazuhiro
Departments of Internal Medicine, Hashimoto Municipal Hospital
-
OKA Tozoh
Departments of Surgery, Hashimoto Municipal Hospital
-
MIYAMOTO Hisao
The Second Department of Internal Medicine, Wakayama Medical College
-
ITOH Hidekazu
The Second Department of Internal Medicine, Wakayama Medical College
関連論文
- PE-301 Kruppel-like Factor 6 is a Key Transcription Factor in Adipocyte Differentiation(PE051,Metabolic Syndrome 3 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-260 Positive Regulation of Promoter-Region Specific Histone Incorporation by Histone Chaperones ANP32B and TAF-I, Histone Deacetylase HDAC1 and DNA-Binding Factor KLF5(PE044,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meet
- DPE-072 A Novel Pathogenic Pathway of DNA Damage Response as Mediated by KLF5 and Its Transcriptional Complexes in the Cardiovasculature(DPE12,Cardiomyopathy/Hypertrophy (Basic) (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of Th
- DPE-067 Kruppel-like Factor 6 Modulates Cardiovascular Fibrosis(DPE12,Cardiomyopathy/Hypertrophy (Basic) (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-398 Different Molecular Forms of Brain Natriuretic Peptide Measured Using Mass Spectrometry-based Immunoassay are a New Biomarker of Coronary Artery Disease(OE67,Coronary Revascularization, PCI (Restenosis/Others) 3 (IHD),Oral Presentation (English),Th
- PE-165 Acyclic Retinoid Inhibits Vascular Remodeling by regulating KLF5(Cardiovascular pharmacology, basic/clinical(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-258 Kruppel-like Factor 6 is a Key Transcription Factor That Controls Cardiac Fibrosis(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-173 A novel pathogenic pathway of DNA damage response as mediated by KLF5 and its transcriptional complexes in the cardiovasculature(Molecular biology, vascular(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circ
- OJ-259 Acyclic Retinoid Inhibits Neointima Formation through Retinoic Acid Receptor Beta-induced Apoptosis(Cardiovascular pharmacology, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-183 Kruppel-like Factor 5 Directly Stimulates Cell Growth in Vascular Lesions(Vascular smooth muscle-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-173 A Novel Regulatory Pathway of DNA Damage Response to Pathologic Vascular Injury as Mediated by KLF5 and its Transcriptional Complexes(Molecular biology, vascular-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-048 Angiotensin II Activates the DNA Damage Response through Nitric Oxide in Vascular Endothelial Cells(Cardiac hypertrophy, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-009 Modulation of Ubiquitin-proteasomal Degradation of KLF5 Influences Vascular Remodeling(Molecular biology, vascular-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-008 Cellular Proteomic Approach to Identify Transforming Growth Factor (TGF)-beta Induced DNA and/or RNA-binding Factors(Molecular biology, vascular-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-299 Acyclic Retinoid is a Possible Oral Therapeutic Agent against Neointimal Hyperplasia(Cardiovascular pharmacology, basic/clinical-1 (H) OE50,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
- OE-023 The Effect of Adenovirus-mediated Overexpression of the Cardiovascular Transcription Factor KLF5 on Vascular Remodeling And Its Mechanism(Molecular biology, vascular-1 (H) OE4,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeti
- Acyclic Retinoid Prevents Cardiovascular Remodeling by Regulated KLF5(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Cardiovascular Transcription Factor Kruppel-like Factor 5 is Negatively Regulated by the Deacetylase HDAC1 through Direct Interaction(Molecular Biology, Vascular 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Proteomic Identification of a Novel Regulatory Pathway of Pathologic Induction of PDGF-A as Mediated by KLF5 with Transcriptional Cofactors(Molecular Biology, Vascular 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-399 Anti-apoptotic effects of the cardiovascular transcription factor KLF5(Apoptosis/Necrosis/Regeneration 2 (M) : PE68)(Poster Session (English))
- Kruppel-Like Zinc-Finger Transcription Factor KLF5/BTEB2 ls a Target for Angiotensin II Signaling and an Essential Regulator of Cardiovascular Remodeling.
- PE-343 Novel Regulatory Pathway of PDGF-A Chain as Mediated by Transcription Factor KLF5 through Cooperative Activation with NF-κB and Phorbol Ester(Molecular Biology, Vascular 3 (H) : PE59)(Poster Session (English))
- OE-273 Acyclic Retinoid Regulates KLF5 And Inhibits Cardiovascular Remodeling(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
- OE-102 Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and SET through interaction and acetylation(Molecular Biology, Vascular 1 (H) : OE12)(Oral Presentation (English))
- OE-100 The Cardiovascular Remodeling Transcription Factor KLF5 Is Negatively Regulated by the Histone Deacetylase HDAC1 through Direct Interaction(Molecular Biology, Vascular 1 (H) : OE12)(Oral Presentation (English))
- Acetylation and Transcriptional Regulation of the Transcription Factor KLF5/BTEB2 by p300 : New Regulatory Pathway of Vascular Transcription
- Proteomic Identification of a Transcriptional Represser of the Transcription Factor KLF5/BTEB2
- KLF/BTEB2-Interacting Protein SET Negatively Regulates KLF5/BTEB2-Induced Cell Growth : a New Target for Therapy against Pathological VSMC Cell Proliferation
- KLF5 not only Synergistically Activates PDGF-A Gene with NFκ B but also Accelerates SMC Proliferation
- OE-114 Kruppel-like Zinc-finger Transcription Factor KLF5/BTEB2 is an Essential Regulator of Cardiovascular Remodeling(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
- FRS-095 KLF5 inhibitor Am80 reduces atherosclerosis in apolipoprotein E-knockout mice.(Inflammation and Cardiovascular Disease (IHD) : FRS12)(Featured Research Session (English))
- KLF5/BTEB2-Interacting Protein SET Inhibits Cell Cycle Progression, Transcription and Induces Apoptosis to Negatively Regulate KLF5/BTEB2
- Mechanisms of maintenance of endothelial function by the aging-suppressor gene Klotho
- Adrenomedullin activates the protein kinase Akt in endothelial cells
- A novel pathway involving the mitogen Trichostatin A and the transcription factor IKLF/BTEB2 in regulation of the SMemb gene
- TAF-1 is a transcriptional cofactor that represses activation by the transcription factor IKLF/BTEB2
- PDGF-A chain is regulated by the transcription factor IKLF/BTEB2
- Transcriptional activation by acetylation of the transcription factor IKLF/BTEB2 by p300
- p300 activates transcription by the transcription factor IKLF/BTEB2 -implications for a role in cell-cycle arrest and differentiation
- Targeted inhibition of the transcription factor IKLF / BTEB2 results in growth arrest of smooth muscle cells
- A Kruppel-like transcription factor IKLF/BTEB2 activates the PDGF promoter in response to angiotensin II in cardiovascular remodeling
- Management of Nodular Goiters and Their Operative Indications
- Spontaneous antibody-secreting cells in the stomach of gastric cancer patients
- Risk of Extra-intestinal Manifestations in Outbreaks of Salmonellosis
- Wegener's Granulomatosis with Dural Involvement as the Initial Clinical Manifestation
- 1 NOVEL TRANSCRIPTIONAL MECHANISMS OF THE VASCULAR PATHOGENIC RESPONSE(Young Investigator's Award Finalists Lectures (YIA))(Special Program)
- A Case of Primary Intrahepatic Sclerosing Cholangitis(PISC) Complicated with Atypical Biliary Epithelial Proliferation.