A Variant Serum Cholinesterase and a Confirmed Point Mutation at Gly-365 to Arg Found in a Patient with Liver Cirrhosis.
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概要
- 論文の詳細を見る
A 64-year-old man was admitted to our hosiptal because of possible liver cirrhosis. His serum cholinesterase was anomalously low with a ΔpH of 0.1 (normal range ; 0.8-1.1). His enzyme was more heat-labile than the normal controls. Km value of his enzyme for benzoylcholine was 1.1×10-5 mol/l, while that for normal controls was 2.3× 10-6 mol/l. In addition, isozymic alteration of his enzyme was observed. Sequencing of the white blood cell DNA of the patient showed a point mutation at nucleotide 1093 (GGA to CGA), which changes codon 365 from glycine to arginine.(Internal Medicine 31 : 357-362, 1992)
- 社団法人 日本内科学会の論文
著者
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MORIWAKI Yuji
the Third Department of Internal Medicine, Hyogo College of Medicine
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HADA Toshikazu
the Third Department of Internal Medicine, Hyogo College of Medicine
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IMANISHI Hiroyasu
The Third Department of Internal Medicine, Hyogo College of Medicine
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HIGASHINO Kazuya
The Third Department of Internal Medicine, Hyogo College of Medicine
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Amuro Yoshiki
The Third Department Of Internal Medicine Hyogo College Of Medicine
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MURATANI Koji
the Third Department of Internal Medicine, Hyogo College of Medicine
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OHUE Toru
the Third Department of Internal Medicine, Hyogo College of Medicine
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ITOH Masami
Department of Internal Medicine, Kinki Central Hospital of the Mutual Aid Association of Public School Teachers
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