A Case of Goodpastures Syndrome Associated with Anti-Myeloperoxidase Antibodies

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概要

• 論文の詳細を見る

• A case of Goodpastures syndrome with anti-myeloperoxidase (MPO) antibodies is reported. Histological examination revealed crescentic glomerulonephritis and alveolar hemorrhage with linear deposition of IgG along the glomerular capillary walls and alveolar capillary walls by immunofluorescence microscopy. Not only anti-glomerular basement membrane (GBM) antibodies but also anti-MPO antibodies, an anti-neutrophil cytoplasmic antibody, were simultaneously detected in the serum. Although it is generally accepted that crescentic glomerulonephritis in Goodpastures syndrome is mediated by anti-GBM antibodies, this case suggested that anti-MPO antibodies might also participate in the pathogenesis of crescentic glomerulonephritis and probably alveolar hemorrhage of Goodpastures syndrome, especially with vasculitis.(Internal Medicine 31 : 239-243, 1992)

著者

• ARIMURA Yoshihiro

  The First Department of Internal Medicine, Kyorin University School of Medicine

• Nakabayashi Kimimasa

  The First Department Of Internal Medicine Kyorin University School Of Medicine

• KAMIYA Yasushi

  The First Department of Internal Medicine, School of Medicine, Kyorin University

• KITAMOTO Kiyoshi

  The First Department of Internal Medicine, School of Medicine, Kyorin University

• NAGASAWA Toshihiko

  The First Department of Internal Medicine, School of Medicine, Kyorin University

• Nagasawa Toshihiko

  The First Department Of Internal Medicine Kyorin University

• Minoshima Shinobu

  The First Department Of Internal Medicine School Of Medicine Kyorin University

• NAKABAYASHI Kimimasa

  The First Department of Internal Medicine, School of Medicine, Kyorin University

関連論文

• Analysis of Risk Epitopes of Anti-Neutrophil Antibody MPO-ANCA in Vasculitis in Japanese Population
• Localization of Myeloperoxidase (MPO) in the Glomeruli of Patients with Anti-MPO Antibodies-associated Crescentic Glomerulonephritis
• Slowly Progressive, Not Rapidly Progressive, MPO-ANCA Positive Glomerulonephritis and Its Characteristics
• A Case Report on the Association of Diabetic Glomerulosclerosis with Generalized Sarcoidosis
• Altered Pharmacokinetics of Prednisolone and Cortisol Suppression During Oral Prednisolone Therapy in Patients with Nephrotic Syndrome
• Simultaneous determination of prednisolone, prednisone, cortisol, and cortisone in plasma by GC-MS : Estimating unbound prednisolone concentration in patients with nephrotic syndrome during oral prednisolone therapy
• Simultaneous determination of tetrahydrocortisol and tetrahydrocortisone in human plasma and urine by stable isotope dilution mass spectrometry
• Renal Vasculitis and Antineutrophil Cytoplasmic Antibody
• A Case of Goodpastures Syndrome Associated with Anti-Myeloperoxidase Antibodies
• Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis : the JMAAV study

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