Anti-Centromere Antibody and CREST Syndrome in Patients with Primary Biliary Cirrhosis.
スポンサーリンク
概要
- 論文の詳細を見る
Anti-centromere antibodies (ACA) in 41 sera from patients with primary biliary cirrhosis (PBC) were analyzed by an immunoblotting method and the correlation between the presence of ACA and the clinical features in these PBC patients was studied. In 10 of 16 ACA-positive PBC patients, one or more clinical features of CREST syndrome (PBC-CREST)were found. Statistical differences were observed in age at disease onset, serum levels of IgM and total bilirubin and titer of anti-M2 antibody, between PBC-CREST patients and the PBC patients without CREST symptoms (PBC-non CREST). By immunoblotting analysis, three major epitopes of ACA were identified at 18kD, 80kD and 140kD polypeptides. The 18kD polypeptides were detected in all 16 ACA-positive PBC patients. From these results, it is suggested that ACA-positive PBC-CREST patients can be separated from ACA-negative PBC-CREST and PBC-non CREST patients.(Internal Medicine 31 : 1348-1355, 1992)
- 社団法人 日本内科学会の論文
著者
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TAKAGI Tohru
the Department of Internal Medicine II, Fukushima Medical College
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Kasukawa Reiji
The Department Of Internal Medicine Ii Fukushima Medical University School Of Medicine
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SHOJI Isao
the Department of Internal Medicine II, Fukushima Medical College
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