Effect of Interferon(IFN) on Refractory Idiopathic Thrombocytopenic Purpura: Administration of 6 Million Units of Recombinant IFN alpha-2b.

概要

論文の詳細を見る
Five patients (six courses) with refractory idiopathic thrombocytopenic purpura (ITP) were given 6 million units of recombinant interferon (IFN) alpha-2b in 12 doses to achieve an improved response rate compared to previous studies using 3 million units. From the initial IFN administration, the platelet count increased from a pre-treatment level of 20.7±17.7×103/μl (mean±SD) and reached its first peak in weeks 2 or 3 of therapy (p<0.05). In week 5, the platelet count made its second and maximum peak (66.5±57.9×103/μl ; p<0.05). A relatively good response of the platelet count (an increase to >50×103/μl) was observed in three patients (four courses) out of five. These responses were not much faster or more improved than in previous reports, and a dose of 6 million units may be too large to treat some ITP patients. The platelet-associated IgG level showed a tendency to be reduced with IFN therapy. The mechanism for the increase of the platelet count may be the modification of platelet autoantibody production.(Internal Medicine 31 : 1343-1347, 1992)
社団法人　日本内科学会の論文