Virus-Associated Demyelination in the Pathogenesis of Bell's Palsy.

スポンサーリンク

概要

• 論文の詳細を見る

• We examined the cerebrospinal fluid findings, including the activity of the myelin-associated enzyme 2', 3'-cyclic nucleotide 3'-phosphohydrolase (CNP), and virus serology in patients with Bell's palsy. Eighty-nine of 164 patients showed hematological and/or serological evidence of an inflammatory reaction. Examinations of the CSF disclosed an elevated total protein level and pleocytosis in 33% and 10% of the 91 patients, respectively. The activity of CNP was significantly elevated in the patient group (15.5±3.8nmol/h/ml) as compared with the control (13.2±1.3nmol/h/ml) (p < 0.01), suggesting the presence of intrathecal myelin breakdown. Furthermore, there was an association between antibodies against herpes simplex virus (HSV) and elevated CNP activity. The inflammatory alterations and accompanying spinal fluid abnormalities, together with the high frequency of HSV antibodies suggest that HSV-associated demyelination may play a pathogenetic role in Bell's palsy.(Internal Medicine 31 : 1250-1256, 1992)

• 社団法人　日本内科学会の論文

著者

• Takahashi Akira

  The Department Of Clinical Laboratory Nagoya University Hospital

• HONDA Hitoshi

  the Department of Neurology, Nagoya University School of Medicine

関連論文

• Orthostatic Hypotension and Postprandial Hypotension
• Survival of Patients with Multiple System Atrophy.
• Sleep Apnea and Palatal Myoclonus in a Patient with Neuro-Behcet Syndrome.
• EEG Changes during Mental Calculation, Reverse Recitation and Association Exercises in Patients with Dementia of the Alzheimer Type.
• Dural Arteriovenous Malformation and Sinus Thromboses in a Patient with Prostate Cancer: An Autopsy Case.
• Virus-Associated Demyelination in the Pathogenesis of Bell's Palsy.

スポンサーリンク