Klinefelters Syndrome Accompanied by Diabetes Mellitus and Diabetes Insipidus

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The first case of Klinefelters syndrome accompanied by diabetes insipidus and diabetes mellitus is reported. A 41-year-old man admitted for hyperosmolar diabetic coma with a past history of diabetes insipidus was diagnosed as having Klinefelters syndrome by endocrinological examination and sex chromosome analysis. In this case, glucose tolerance test was normalized half a year later and blood glucose was well controlled with diet therapy alone.(Internal Medicine 31 : 917-921, 1992)