Siblings of 21-Hydroxylase Deficiency (Non-Salt-Losing) with Aldosterone Hypersecretion.
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概要
- 論文の詳細を見る
We describe siblings with the non-salt-losing form of 21-hydroxylase deficiency who had hypersecretion of aldosterone and plasma renin activity (PRA). Blood pressure and serum electrolytes in both cases were normal despite the aldosterone hypersecretion. Aldosterone secretion was elevated markedly with ACTH administration and with sodium deprivation and/or volume depletion during ACTH suppression by dexamethasone. With suppression by dexamethasone, aldosterone hypersecretion was decreased with lowering of the steroids proximal to the block in the biosynthetic pathway. However, urinary sodium excretion was decreased. These results suggest that the biosynthetic pathway for aldosterone production was preserved. Furthermore, aldosterone hypersecretion and high PRA may serve to compensate for the sodium loss which results in turn from the overproduction of the sodium-losing steroids, such as progesterone and 17α-hydroxyprogesterone which are aldosterone antagonists.(Internal Medicine 31 : 690-694, 1992)
- 社団法人 日本内科学会の論文
著者
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Morimoto Isao
The First Department Of Internal Medicine University Of Occupational And Environmental Health
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WATANABE KENICHI
The First Department of Internal Medicine, Niigata University School of Medicine
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NAKANO Yoichiro
The First Department of Internal Medicine, School of Medicine, University of Occupational and Enviro
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Eto Sumiya
The First Department Of Internal Medicine University Of Occupational And Environmental Health
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Zeki Kazuya
The First Department Of Internal Medicine School Of Medicine University Of Occupational And Envirome
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MORIMOTO Isao
the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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NAKANO Yoichiro
the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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YAMAMOTO Shigeki
the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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TATEISHI Hajime
the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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UEDA Singi
the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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TODA Youko
the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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KASHIMURA Masamichi
the First Department of Gynecology, School of Medicine, University of Occupational and Environmental Health
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ETO Sumiya
the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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- Siblings of 21-Hydroxylase Deficiency (Non-Salt-Losing) with Aldosterone Hypersecretion.