Pentasomy X Mosaic in Two Adult Sisters with Diabetes Mellitus
スポンサーリンク
概要
- 論文の詳細を見る
Pentasomy X mosaic in two adult sisters with non-insulin dependent diabetes mellitus is described. The younger sister had schizophrenia, and both were mentally retarded, but no apparent somatic abnormalities were found. Chromosome analyses revealed karyotype 45, X/46, XX/47, XXX/48, XXXX/49, XXXXX mosaic with a low frequency of aneuploidy on cultured peripheral lymphocytes and 46, XX on cultured skin fibroblasts in both sisters. The low frequency of X chromosome aberration may be responsible for the lack of somatic abnormalities and the long life in both sisters. The association of pentasomy X mosaicism and diabetes mellitus however appears to be coincidental.(Internal Medicine 31 : 1102-1106, 1992)
著者
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NAKANO Shigeru
the Devision of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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KIGOSHI Toshikazu
the Devision of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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UCHIDA Kenzo
the Devision of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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Morimoto Shinpei
The Division Of Endocrinology Department Of Internal Medicine
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UCHIDA Kenzo
the Division of Endocrinology, the Department of Internal Medicine, Kanazawa Medical University
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TAKAHASHI Hiroaki
the Division of Human Genetics, Medical Research Institute, Kanazawa Medical University
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SASAME Atsuko
the Division of Endocrinology, the Department of Internal Medicine, Kanazawa Medical University
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AZUKIZAWA Sadahide
the Division of Endocrinology, the Department of Internal Medicine, Kanazawa Medical University
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