Parathyroid Horomone-Related Protein as a Cause of Hypercalcemia in a B-cell Type Malignant Lymphoma.
スポンサーリンク
概要
- 論文の詳細を見る
Hypercalcemia occurred in a patient with non-Hodgkin's (B-cell type) lymphoma when generalized lymphadenopathy developed. Despite low normal plasma parathyroid hormone (PTH), nephrogenous cAMP (NcAMP) was not suppressed, and serum and urine PTH-related protein (PTH-rP) levels were elevated. The plasma level of 1, 25 (OH) 2D was within normal range. The combined chemotherapies successfully reduced the tumor size, serum Ca, PTH-rP, and lactic dehydrogenase. Serum osteocalcin was suppressed while the patient was hypercalcemic, and increased after chemotherapy. In the extract of the tumor tissue obtained post mortem, bioactivity stimulating the production of CAMP in osteoblasts was demonstrated along with the immunoreactive PTH-rP. This is the first report of a B-cell lymphoma producing PTH-rP and its association with humoral hypercalcemia of malignancy.(Internal Medicine 31 : 968-972, 1992)
- 社団法人 日本内科学会の論文
著者
-
Wada Seiki
The Third Department Of Internal Medicine
-
Motoyoshi Kazuo
The Third Department Of Internal Medicine National Defense Medical College
-
Nagata Naokazu
The Third Department Of Internal Medicine
-
KUGAI Nobuo
the Third Department of Internal Medicine
-
KATAYAMA Yasuyuki
the Third Department of Internal Medicine
-
WADA Seiki
the Third Department of Internal Medicine, National Defense Medical College
-
KITAMURA Hideyuki
the Third Department of Internal Medicine, National Defense Medical College
-
MATSUURA Yoshifusa
the Second Department of Pathology, National Defense Medical College
-
OHKAWA Hidenori
the Third Department of Internal Medicine, National Defense Medical College
-
FUSE Yusuke
the Second Department of Pathology, National Defense Medical College
-
NAGATA Naokazu
the Third Department of Internal Medicine, National Defense Medical College
-
KUGAI Nobuo
the Third Department of Internal Medicine, National Defense Medical College
関連論文
- Magnetic Resonance Imaging of Multiple Brain Abscesses of the Bilateral Basal Ganglia
- Non-Cushingoid Cushing's Syndrome due to Adrenocorticotropic Hormone-Independent Bilateral Adrenocortical Macronodular Hyperplasia
- Augmentation of Cancer Chemotherapy by Preinjection of Human Macrophage Colony-stimulating Factor in L1210 Leukemic Cell-inoculated Mice
- Ploycystic Kidney Disease Associated with Cervical Arteriovenous Shunt and Bilateral Jugular Vein Occlusion
- Prolonged central sensory conduction time in alcoholics with hypoactive aldehyde dehydrogenase-2
- Motor Dominant Neuropathy in Sjogren's Syndrome : Report of Two Cases
- ACCUMULATION OF GERMANIUM IN THE TISSUES OF A LONG-TERM USER OF GERMANIUM PREPARATION DIED OF ACUTE RENAL FAILURE
- A Case of Anorexia Nervosa with Acute Renal Failure Induced by Rhabdomyolysis; Possible Involvement of Hypophosphatemia or Phosphate Depletion.
- Parathyroid Horomone-Related Protein as a Cause of Hypercalcemia in a B-cell Type Malignant Lymphoma.
- Diurnal Change in Heart Rate Variability in Healthy and Diabetic Subjects.
- Primary Mediastinal Diffuse Large Cell Lymphoma Initially Presented with Pericardial Infiltration.
- Changes of Bone Metabolic Markers in Patients with Bone Metastases: Clinical Significance in Assessing Bone Response to Chemotherapy.