Detection of Monoclonal Hematopoiesis Using Restriction Fragment Length Polymorphism(RFLP) of Phosphoglycerokinase(PGK) Gene in a Patient with Hypoplastic Myelodysplastic Syndrome(MDS).
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概要
- 論文の詳細を見る
A clonal analysis of hematopoiesis in a hypoplastic MDS patient was performed. Monoclonal utilization of PGK gene on her two X chromosomes was detected by Southern blot analysis of the bone marrow cells using a PGK probe after methylation-sensitive restriction enzyme treatment. This is compatible with monoclonal construction of her hematopoiesis, confirming MDS nature with a progression of her morphological dysplasia in bone marrow cells. RFLP of PGK gene on X chromosome is thus useful to detect a monoclonality in hematopoietic diseases.(Internal Medicine 32: 255-256, 1993)
- 社団法人 日本内科学会の論文
著者
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MIYAZAKI Yasushi
The Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine
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TOMONAGA Masao
the Department of Haematology of Atomic Disease Institute, Nagasaki University School of Medicine
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Kuriyama Kazutaka
The Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Univ
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HIRASHIMA Kunitake
the First Department of Internal Medicine, Saitama Medical School
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FUJWARA Tsuneo
the Department of Internal Medicine, Ohmura Municipal Hospital
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JINNAI Itsuro
the First Department of Internal Medicine, Saitama Medical School
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TOMONAGA Masao
the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
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KURIYAMA Kazutaka
the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
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- Detection of Monoclonal Hematopoiesis Using Restriction Fragment Length Polymorphism(RFLP) of Phosphoglycerokinase(PGK) Gene in a Patient with Hypoplastic Myelodysplastic Syndrome(MDS).
- Immune Pathology of Myelodysplastic Syndromes