Increased 1,25-(OH)2D2 Concentration in a Patient with Malignancy-Associated Hypercalcemia Receiving Intravenous Hyperalimentation Inadvertently Supplemented with Vitamin D2.
スポンサーリンク
概要
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A 55-year-old patient with hypercalcemic crisis due to gastric carcinoma with bone marrow metastasis was treated with bisphosphonate (pamidronate) and calcitonin. Urinary excretion of parathyroid hormone-related protein (PTHrP) was increased. When normocalcemia had been attained, intravenous hyperalimentation was started, in which 1, 000 U vitamin D2 was inadvertently supplemented on days 5-18, On days 15-18, hypercalcemia rapidly recurred, accompanied by markedly increased serum levels of 25-OHD2 (9.1 ng/dl) and 1, 25-(OH)2D2 (161 pg/ml). This clinical course suggests that PTHrP, like PTH, stimulated 1α-hydroxylase activity and produced excessive 1, 25-(OH)2D2. Vitamin D should not be administered to patients with malignancyassociated hypercalcemia, particularly that due to PTHrP-producing tumors.(Internal Medicine 32: 886-890, 1993)
- 社団法人 日本内科学会の論文
著者
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Demura Hiroshi
The Department Of Medicine
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SATO Kanji
The Department of Medicine
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TORAYA Shozo
The Department of Medicine
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Tanaka Masato
The Department Of Electronic Engineering Graduate School Of Engineering The University Of Tokyo
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Kobayashi Tadashi
The Division Of Respiratory Medicine And Allergology Department Of Internal Medicine Aichi Medical University School Of Medicine
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TAKEUCHI Atsuko
the Department of Hygienic Sciences, Kobe Women's College of Pharmacy
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IMAKI Toshihiro
the Department of Medicine, Institute of Clinical Endocrinology
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KASAJIMA Takeshi
the Department of Pathology, Tokyo Women's Medical College
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SATO Kanji
the Department of Medicine, Institute of Clinical Endocrinology
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TANAKA Masato
the Department of Pathology, Tokyo Women's Medical College
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KASAJIMA Takeshi
the Department of Pathology, Tokyo Women's Medical College
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