Response to Octreotide of Intestinal Pseudoobstruction and Pneumatosis Cystoides Intestinalis Associated with Progressive Systemic Sclerosis.

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Intestinal pseudoobstruction and pneumatosis cystoides intestinalis are uncommon complications of progressive systemic sclerosis. We report a 26-year-old woman with this disorder who responded poorly to conventional treatment. Subcutaneous administration of octreotide, a longacting somatostatin analogue, at a dose of 50 μg/day for 3 weeks, relieved symptoms such as nausea and bloating. There was also a marked decrease of intestinal gas accumulation, as documented on X-ray films.(Internal Medicine 32: 607-609, 1993)
社団法人　日本内科学会の論文