Pneumocystis carinii Pneumonia Monitored by P. carinii Shedding in Sputum by the Polymerase Chain Reaction.

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概要

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• This study investigated the efficacy of applying the polymerase chain reaction (PCR) technique to the monitoring of therapy to P. carinii pneumonia (PCP). The PCR method was sensitive enough to determine P. carinii shedding in sputum samples which was not detectable by Diff-Quik (International Reagent Corp., Kobe, Japan) stain. By PCR, P. carinii disappeared in sputa on days 8 to 15 after treatment. Clinical improvements correlated with the loss of detectable P. carinii. This study represents a potential usefulness of PCR to monitor P. carinii shedding in sputum during treatment.(Internal Medicine 32: 370-373, 1993)

著者

• KIMURA Satoshi

  Infectious Diseases, Institute of Medical Science, University of Tokyo

• KITADA Kazuhiro

  the Departments of Tumor Biology, Institute of Medical Science, University of Tokyo

• OKA Shinichi

  Infectious Diseases, Institute of Medical Science, University of Tokyo

• KOHJIN Takami

  Infectious Diseases, Institute of Medical Science, University of Tokyo

• NAKAMURA Yoshikazu

  the Departments of Tumor Biology, Institute of Medical Science, University of Tokyo

• SHIMADA Kaoru

  Infectious Diseases, Institute of Medical Science, University of Tokyo

関連論文

• Pneumocystis carinii Pneumonia Monitored by P. carinii Shedding in Sputum by the Polymerase Chain Reaction.

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