A MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes) mtDNA Mutation that Induces Subacute Dementia which Mimicks Creutzfeldt-Jakob Disease.

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概要

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• A 50-year-old woman with subacute dementia and brain atrophy on CT showed periodic synchronous discharge (PSD) on electroencephalogram (EEG) and myoclonus. She was initially suspected of suffering from Creutzfeldt-Jakob disease (CJD), but dramatically recovered over 5 months. Based on further investigations, the final diagnosis was mitochondria! encephalomyopathy with an A-to-G substitution at nucleotide position 3243 in mitochondrial DNA (mtDNA), commonly seen in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS). This case suggests that patients suspected of suffering from CJD should be evaluated for mitochondrial encephalomyopathy.(Internal Medicine 33: 543-546, 1994)

• 社団法人　日本内科学会の論文

著者

• Fukuuchi Yasuo

  The Department Of Neurology Keio University School Of Medicine

• Nogawa Shigeru

  The Department Of Internal Medicine Keio University School Of Medicine

• FUKUUCHI Yasuo

  the Department of Neurology, Keio University School of Medicine

• ISHIHARA Tadayuki

  The Department of Internal Medicine, National Higashisaitama Hospital

• ISOZUMI Kazuo

  The Department of Neurology, Keio University School of Medicine

• TANAKA Kortaro

  The Department of Neurology, Keio University School of Medicine

• SAKUTA Ryoichi

  The Division of Ultrastructural Research, National Institute of Neuroscience, NCNP

関連論文

• Myasthenia-Like Syndrome Induced by Overdosage of Cibenzoline
• Single-Photon Emission Computed Tomography Image of Benzodiazepine Receptors in a Patient with Creutzfeldt-Jakob Disease
• A MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes) mtDNA Mutation that Induces Subacute Dementia which Mimicks Creutzfeldt-Jakob Disease.

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