Selegiline (L-Deprenyl) and L-Dopa Treatment of Parkinson's Disease: A Double-Blind Trial.

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概要

• 論文の詳細を見る

• To confirm the clinical utility of selegiline (L-deprenyl), a selective inhibitor of monoamine oxidase B, as an anti-Parkinson's disease (PD) agent, the first Japanese multi-center, double-blind comparative study of this drug was conducted. The subjects were patients who had responded poorly or suffered with other problems related to L-dopa treatment. A total of 112 patients in two groups, one given selegiline at a dose of 7.5 mg/day (Group D, n=60) and another given a placebo (Group P, n=52), were compared over an 8-week treatment period. The percentage patients showing "moderate improvement" or better was 34.5% in Group D, while that in Group P was 11.5 % (P<0.01). In the assessment of overall safety, 66.7 % in Group D showed no adverse reactions, which was not significantly different from the result of 78.9% for Group P.(Internal Medicine 33: 517-524, 1994)

• 社団法人　日本内科学会の論文

著者

• Tachibana Hisao

  The Fifth Department Of Internal Medicine Hyogo College Of Medicine

• Takahashi Mitsuo

  The Department Of Information And Computer Sciences Toyohashi University Of Technology

• YORIFUJI Shiro

  The Department of Neurology, Osaka University School of Medicine

• YUASA Ryoichi

  The Department of Neurology, Sakai Municipal Hospital

• IMAI Terukuni

  The Department of Neurology, Tazukekoufukai Kitano Hospital

• NAKAMURA Yusaku

  The Department of Neurology, Kinki University School of Medicine

• OGAWA Nobuya

  The Department of Pharmacology, Ehime University School of Medicine

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• Selegiline (L-Deprenyl) and L-Dopa Treatment of Parkinson's Disease: A Double-Blind Trial.

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