Inhibition of Collagen Production by Traditional Chinese Herbal Medicine in Scleroderma Fibroblast Cultures.
スポンサーリンク
概要
- 論文の詳細を見る
The in vitro effect of one traditional Chinese herbal medicine (Japanese name: "Keishi-bukuryo-gan"), which has been empirically used in scleroderma patients in China and Japan, on collagen production in tibroblast cultures was studied. Fibroblasts from 3 scleroderma patients and 2 normal controls were incubated with various concentrations of "Keishi-bukuryo-gan" and collagen production was then determined by a radiochemical method. "Keishi-bukuryo-gan" significantly and selectively inhibited collagen synthesis in a dose-dependent manner, with a tendency of a stronger effect on scleroderma fibroblasts than control cells. The results may explain the clinical usefulness of this medicine, and it may become a promising new agent for the treatment of scleroderma.(Internal Medicine 33: 466-471, 1994)
- 社団法人 日本内科学会の論文
著者
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Yamaguchi Masaya
The Department Of Internal Medicine Saga Medical School
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OHTA Akihide
the Department of Clinical Nursing, Saga Medical School
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OHTA Akihide
The Division of Rheumatology and Allergy, the Department of Internal Medicine, Saga Medical School
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SHENG Fan
The Division of Rheumatology and Allergy, the Department of Internal Medicine, Saga Medical School
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YAMAGUCHI Masaya
The Division of Rheumatology and Allergy, the Department of Internal Medicine, Saga Medical School
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