Study of the Myocardial Nucleic Acids and Proteins Metabolism in Experimentally Induced Cardiac Hypertrophy and Heart Failure

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概要

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• In the present experiment, the incorporation ratios of glycine-2-C14 into nucleic acids and proteins extracted from various subcellular fractions were determined in the left ventricular hypertrophy and cardiac failure induced by aortic constriction. 1) The specific radioactivity of DNA increased only in the cardiac failure. 2) The so-called m-RNA was activated at an early stage and late stage of aortic constriction. The late stage meant the early stage of ventricular failure. 3) The mitochondrial and nuclear RNA were activated only in the compensated hypertrophy. 4) The incorporation ratio of microsomal, contractile proteins were considerably high in the hypertrophied muscle, but returned to normal in failing muscle. 5) The mitochondrial, cytoplasmic, and nuclear proteins showed high specific radioactivity only during compensated stage. 6) The results obtained were discussed concerning the mechanism of cardiac hypertrophy and failure.

• International Heart Journal刊行会の論文

著者

• KAKU Isaomi

  Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• Study of the Myocardial Nucleic Acids and Proteins Metabolism in Experimentally Induced Cardiac Hypertrophy and Heart Failure

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