A Long-Survival Case of Systemic AL Amyloidosis with Nephrotic Syndrome

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概要

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• A 49-year-old Japanese female was initially diagnosed as having monoclonal gammopathy of undetermined significance in June 1993 (IgGλ: 3, 120 mg/dl). Four years later, she developed AL amyloidosis complicated by nephrotic syndrome and renal failure. Before receiving 5 courses of MP therapy (melphalan plus prednisolone), her serum IgG level had decreased in accordance with the appearance of nephrotic syndrome, which led to the leakage of serum immunoglobulin into the urine. After the discontinuation of the MP therapy, hypogammaglobulinemia has been kept over 24 months, though she still shows a leakage of 4-5 g/day of serum protein, including IgG into the urine. There were no signs of the progression of amyloidosis or renal failure, resulting in a good clinical performance status. Hypogammaglobulinemia due to nephrotic syndrome may have prevented the progression of AL amyloidosis in this case.(Internal Medicine 41: 1052-1055, 2002)

• 社団法人 日本内科学会の論文
• 2002-11-01

著者

• OHYASHIKI Kazuma

  First Department of Internal Medicine (Division of Hematology), Tokyo Medical University

• MIYAZAWA Keisuke

  First Department of Internal Medicine, Tokyo Medical University

• SERIZAWA Hiromi

  Department of Surgical Pathology, Tokyo Medical University

• SERIZAWA Hiromi

  The Department of Pathology, Tokyo Medical College

• Ohyashiki K

  Tokyo Medical Univ. Tokyo Jpn

• Ohyashiki Kazuma

  First Department Of Internal Medicine (division Of Hematology) Tokyo Medical University

• Ohyashiki Kazuma

  First Department Of Internal Medicine (hematology Division) Tokyo Medical University

• Miyazawa Keisuke

  日本医科大学 第三内科

• GOTOH Akihiko

  Hematology Division, Tokyo Medical University

• Ohyashiki Kazuma

  First Deparmtne Of Internal Medicine Tokyo Medical University

• Gotoh Akihiko

  Hematology Division Tokyo Medical University

• Serizawa Hiromi

  The Department Of Surgical Pathology Tokyo Medical University

• KATAGIRI Tomoko

  the First Department of Internal Medicine, Tokyo Medical University

• MIYAZAWA Keisuke

  the First Department of Internal Medicine, Tokyo Medical University

• YAHATA Naoyuki

  the First Department of Internal Medicine, Tokyo Medical University

• GOTOH Akihiko

  the First Department of Internal Medicine, Tokyo Medical University

• OYASHIKI Kazuma

  the First Department of Internal Medicine, Tokyo Medical University

• Yahata Naoyuki

  The First Department Of Internal Medicine Tokyo Medical University

• Kawai T

  First Deparmtne Of Internal Medicine Tokyo Medical University

• Katagiri Tomoko

  The First Department Of Internal Medicine Tokyo Medical University

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