A New Serum Antibody Test Kit (E Plate) for Evaluation of Helicobacter Pylori Eradication

スポンサーリンク

概要

• 論文の詳細を見る

• Objective Serological antibody test have been widely performed to detect the presence of H. pylori, but they have not been used to evaluate the status of H. pylori after eradication. In this study we evaluated the diagnostic accuracy of a new serological test kit (E-plate) after eradication.<br>Method Eradication of H. pylori was performed in 100 patients by proton pump inhibitor (PPI)+amoxicillin (AMPC)+clarithromycin (CAM) or PPI+AMPC therapy. Evaluation of H. pylori was done by culture, histology and rapid urease test before, and 8 weeks after, the treatment. Serological tests were also performed before and after treatment using the E plate. Cure was defined as no evidence of H. pylori at 8 weeks after the treatment. Receiver operating characteristic (ROC) analysis was performed to determine the ideal cut-off value for percentage change in the serological test.Result Success was obtained in 73 patients, failure in 20 patients and there were 7 dropouts. Serological test value was significantly decreased after treatment (44.3±29.6 U/ml) compared to before treatment (94.8±73.2 U/ml) in the successful cases. In contrast, those with no significant change after treatment (62.7±31.3 U/ml) compared to before treatment (72.9±47.7 U/ml) were considered as failure cases. ROC analysis revealed that cut-off values of a 20%, 30%, and 40% decrease on E plate result yielded a sensitivity of 95.5%, 92.4%, 71.2% and a specificity of 73.3%, 84.2%, 94.7%, respectively.Conclusion The new E plate serological test kit for H. pylori was useful for distinguishing success from failure 8 weeks after completion of eradication therapy for H. pylori.(Internal Medicine 41: 780-783, 2002)

• 社団法人 日本内科学会の論文
• 2002-10-01

著者

• Kudo Taku

  The Fourth Department Of Internal Medicine Tokyo Medical University

• Handa Yutaka

  The Fourth Department Of Internal Medicine Tokyo Medical University

• Ogiahara Shoji

  The Fourth Department Of Internal Medicine Tokyo Medical University

• Kawakami Kohei

  The Fourth Department Of Internal Medicine Tokyo Medical University

• Moriyasu Fuminori

  The Fourth Department Of Internal Medicine Tokyo Medical University

• Kawai Takashi

  The Fourth Department Of Internal Medicine Tokyo Medical University

• MORIYASU Fuminori

  the First Department of Internal Medicine, Faculty of Medicine, Kyoto University

関連論文

• CORRELATION BETWEEN SERUM PEPSINOGEN LEVELS AND GASTRIC MUCOSAL HISTOLOGICAL FINDINGS BEFORE AND AFTER HELICOBACTER PYLORI ERADICATION THERAPY
• A New Serum Antibody Test Kit (E Plate) for Evaluation of Helicobacter Pylori Eradication
• Diagnosis of NASH using delayed parenchymal imaging of contrast ultrasound
• A New Serum Antibody Test Kit (E Plate) for Evaluation of Helicobacter Pylori Eradication
• Distribution of Mesenteric and Splenic Blood Flow in Cirrhosis of the Liver as Estimated byRadionuclide Angiography.

スポンサーリンク