Cellular Crescents and Segmental Glomerular Necrosis in IgA Nephropathy Are Indicative of the Beneficial Effects of Corticosteroid Therapy.

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概要

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• Objective Recent reports have revealed that corticosteroid (PSL) therapy has a long-term beneficial effect for stabilization of renal function in progressive IgA nephropathy. Patients and methods We analyzed serum creatinine (Cr), daily proteinuria and the results of other routine laboratory examinations during a short-term course of PSL therapy in 28 cases of progressive IgA nephropathy. The cases were divided into two groups according to changes in renal function during the PSL treatment period: group I (15 cases), improved renal function; group II (13 cases), no significant change in renal function. Results In group I, serum Cr and proteinuria were significantly decreased, with maximum effects observed at 3 months of PSL therapy, and remained low during the period of treatment. In contrast, group II showed no significant changes in serum Cr levels during the period of therapy, although proteinuria was transiently decreased after 3 months of therapy. Histologically, cellular/fibrocellular (C/F) crescents and/or segmental glomerular necrosis (SGN) occurred with a significantly higher incidence in group I (87%) than in group II (46%) (p<0.05). Conclusions These results suggested that the early response to PSL in reducing serum Cr and proteinuria by 3 months of treatment may be clinically useful to predict the prognosis of IgA nephropathy and that C/F crescents and/or SGN may be histologically indicative of the beneficial effects of PSL therapy in IgA nephropathy.(Internal Medicine 40: 862-866, 2001)

• 社団法人　日本内科学会の論文

著者

• TOMIYOSHI Yoshiyuki

  the Department of Internal Medicine, Saga Medical School

• FUJISAKI Taisei

  the Department of Internal Medicine, Saga Medical School

• Sakemi Takanobu

  The Department Of Internal Medicine Saga Medical School

• Ikeda Yuji

  The Department Of Internal Medicine Saga Medical School

• Nakamura Megumi

  The Department Of Internal Medicine Saga Medical School

• Fujisaki Taisei

  The Department Of Internal Medicine Saga Medical School

• OHTSUKA Yoko

  the Department of Internal Medicine

関連論文

• Cellular Crescents and Segmental Glomerular Necrosis in IgA Nephropathy Are Indicative of the Beneficial Effects of Corticosteroid Therapy
• Localized Myxedema, Associated with Increased Serum Hyaluronic Acid, and Response to Steroid Pulse Therapy
• Acute Myelogenous Leukemia Following Treatment with Cyclosporin A in a Nephrotic Patient
• Acute Myelogenous Leukemia Following Treatment with Cyclosporin A in a Nephrotic Patient.
• Cellular Crescents and Segmental Glomerular Necrosis in IgA Nephropathy Are Indicative of the Beneficial Effects of Corticosteroid Therapy.

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