Propylthiouracil-induced Lupus-like Syndrome Developing in a Graves' Patient with a Sibling with Systemic Lupus Erythematosus

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概要

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• A 13-year-old girl with Graves disease, whose younger sister had systemic lupus erythematosus, developed polyarthralgia, fever, neutropenia, hypergammaglobulinemia, and microscopic hematuria after treatment with propylthiouracil (PTU) for 2 years. Myeloperoxidaseanti-neutrophil cytoplasmic antibodies were strongly positive. Anti-single- and anti-double-stranded DNA antibodies were positive, whereas LE cells and anti-Sm antibodies were negative. PTU was discontinued and all symptoms subsided gradually. Two years later, the microscopic hematuria had disappeared completely. Both patients had the identical HLA-DR alleles (HLA-DR9). These present two cases in siblings suggest that both sisters had lupus diathesis, and that the elder sister developed a PTU-induced lupus-like syndrome.(Internal Medicine 41: 1204-1208, 2002)

• 社団法人 日本内科学会の論文
• 2002-12-01

著者

• Hara Mitsuhiko

  Tokyo Metropolitan Hiroo General Hospital

• Hizuka Naomi

  Institute Of Clinical Endocrinology Tokyo Women's Medical University

• Takano Kazue

  Institute Of Clinical Endocrinology Tokyo Women's Medical University

• TAKAGI SACHIKO

  Institute of Clinical Endocrinology, Department of Medicine, Tokyo Women's Medical University School

• Sato Kanji

  Instiute Of Clinical Endocrinology Tokyo Women's Medical University

• YAMADA Akemi

  Institute of Clinical Endocrinology, Tokyo Women's Medical University

• TOCHIMOTO Akiko

  Institute of Clinical Endocrinology, Tokyo Women's Medical University

• Yamada Akemi

  Institute Of Clinical Endocrinology Tokyo Women's Medical University

• Takagi Sachiko

  Institute Of Clinical Endocrinology Tokyo Women's Medical University

• Tochimoto Akiko

  Institute Of Clinical Endocrinology Tokyo Women's Medical University

• Takano Kazue

  Institute Of Clinical Endocrinology Department Of Medicine Tokyo Women's Medical University Sch

• SATO Kanji

  Institute of Clinical Endocrinology, Tokyo Women's Medical University

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• Propylthiouracil-induced Lupus-like Syndrome Developing in a Graves' Patient with a Sibling with Systemic Lupus Erythematosus
• Propylthiouracil-induced Lupus-like Syndrome Developing in a Graves' Patient with a Sibling with Systemic Lupus Erythematosus
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