Epstein-Barr Virus Infections of the Central Nervous System
スポンサーリンク
概要
- 論文の詳細を見る
Objective Epstein-Barr virus (EBV), a lymphotropic herpes virus causing infectious mononucleosis (IM), also causes various central nervous system (CNS) infections. In the present study, EBV CNS infections were investigated. Patients and Methods For adult inpatients in our hospital and related hospitals between 1984-2002, CNS syndromes with IM symptoms were examined, and serologic positives were assessed according to established criteria. Polymerase chain reaction (PCR) was performed for cerebrospinal fluid (CSF) from seven patients. Results Ten patients with EBV-related CNS infections were found; their mean age was 36 years (20-79 years). The neurologic forms were as follows: acute encephalitis (4 patients), acute cerebellar ataxia (1), acute disseminated encephalomyelitis (ADEM) (2), myelitis (1), and meningitis (2). The PCR from CSF was positive in two patients with meningitis, one patient with ADEM, and one patient with encephalitis-associated chronic EVB infection. One case of encephalitis and another of relapsing ADEM were attributed to chronic EBV infection. Conclusion Our study identified a variety of EBV related CNS infections. EBV CNS infections are divided into two groups: 1) CNS syndromes associated with primary EBV or reactivated infection, and 2) those associated with chronic EBV infection; it is notable that in the former, diverse CNS syndromes including ADEM can occur, whereas in the latter, chronic or recurrent CNS syndromes are produced.(Internal Medicine 42: 33-40, 2003)
- 社団法人 日本内科学会の論文
- 2003-01-01
著者
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Ayabe Mitsuyoshi
The First Department Of Internal Medicine Kurume University School Of Medicine
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Imaizumi Toshihiro
The First Department Of Internal Medicine Kurume University School Of Medicine
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FUJIMOTO Hiroshi
the First Department of Internal Medicine, Kurume University School of Medicine
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ASAOKA Kyoko
the First Department of Internal Medicine, Kurume University School of Medicine
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SHOJI Hiroshi
the First Department of Internal Medicine, Kurume University School of Medicine
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KAJI Masahide
Internal Medicine, Kurume Medical Center, Kurume University School of Medicine
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Asaoka Kyoko
The First Department Of Internal Medicine Kurume University School Of Medicine
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Kaji Masahide
Internal Medicine Kurume Medical Center Kurume University School Of Medicine
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Shoji Hiroshi
First Department Of Internal Medicine Kurume University School Of Medicine
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Ayabe Mitsuyoshi
First Department Of Internal Medicine Kurume University School Of Medicine
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Fujimoto Hiroshi
The First Department Of Internal Medicine Kurume University School Of Medicine
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Fujimoto Hiroshi
the First Department (Neurololgy) of Internal Medicine
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SHOJI Hiroshi
The First Department (Neurology) of Internal Medicine, Kurume University
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AYABE Mitsuyoshi
The First Department (Neurology) of Internal Medicine, Kurume University of Medicine
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IMAIZUMI Toshihiro
The First Department (Neurology) of Internal Medicine, Kurume University
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FUJIMOTO Hiroshi
The First Department (Neurology) of Internal Medicine, Kurume University
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