Different Risk Factors for the Maximum and the Mean Carotid Intima-media Thickness in Hemodialysis Patients
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概要
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Objective High-resolution B-mode ultrasonography has been widely used for the noninvasive assessment of atherosclerosis in hemodialysis patients. But, there are two major methods of carotid ultrasonography: one including plaque and the other excluding plaque. Methods The subjects were 112 hemodialysis patients (58 men and 54 women) with a mean age of 55.8±13.0 years. The maximum intima-media thickness (IMT) of the carotid artery (including plaque) was measured as an index of arterial wall thickening and atheroma formation, while the mean IMT (without plaque) was measured as an index of arterial wall thickening. In addition the value of (maximum-mean) IMT was calculated as an index of atheroma formation. Therefore, the independent risk factors associated with the maximum IMT, mean IMT, and (maximum-mean) IMT were investigated by stepwise multiple regression analysis. Results The independent risk factors associated with the maximum IMT were age, diabetes mellitus, smoking, and intact parathyroid hormone (PTH) (R=0.569, p<0.0001), while factors associated with the mean IMT were age, hypertension, dyslipidemia, intact PTH, and lipoprotein (a) (R=0.602, p<0.0001). The independent risk factors associated with the (maximum-mean) IMT were age, diabetes mellitus, smoking, and intact PTH (R=0.515, p<0.0001). Conclusion These findings suggest that risk factors for the maximum IMT and mean IMT are somewhat different in hemodialysis patients.(Internal Medicine 42: 1095-1099, 2003)
- 社団法人 日本内科学会の論文
- 2003-11-01
著者
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Ito Takafumi
Section Of Nephrology Department Of Internal Medicine Shimane University Faculty Of Medicine
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ITO Takafumi
Department of Surgery II, Nagoya University School of Medicine
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Masaki Takao
Department Of Advanced Nephrology Graduate School Of Biomedical Sciences Hiroshima University
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SHIGEMOTO Kenichiro
Department of Internal Medicine, Harada Hospital
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HARADA Satoru
Department of Internal Medicine, Harada Hospital
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Yorioka Noriaki
Hiroshima Univ. Hiroshima Jpn
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Yorioka Noriaki
Department Of Advanced Nephrology Graduate School Of Biomedical Sciences Hiroshima University
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Nakashima Ayumu
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Nakashima Ayumu
Department Of Dental And Medical Biochemistry Hiroshima University Graduate School Of Biomedical Sci
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ASAKIMORI Yukiteru
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
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Harada Satoru
Department Of Internal Medicine Harada Hospital
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Shigemoto Kenichiro
Department Of Internal Medicine Harada Hospital
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Yorioka Noriaki
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Ito Takafumi
Department Of Applied Physics Nagoya University
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Asakimori Yukiteru
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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