Half Pitch Lower Sound Perception Caused by Carbamazepine

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概要

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• We report a 16-year-old woman with secondary generalization of partial seizure, who complained of an auditory disturbance after carbamazepine (CBZ) administration. She had been taking sodium valproate (VPA) from the age of 15. However, her seizures remained poorly controlled. We changed her antiepileptic drug from VPA to CBZ. At 1 week after CBZ administration, she noticed that electone musical performances were heard as a semitone lower. When oral administration of CBZ was stopped, her pitch perception returned to normal. If she had not been able to discern absolute pitch, she might have been unable to recognize her lowered pitch perception. Auditory disturbance caused by CBZ is reversible and very rare.(Internal Medicine 42: 880-883, 2003)

• 社団法人　日本内科学会の論文

著者

• ABE Takashi

  the Department of Internal Medicine, Yamagata University School of Medicine, Yamagata

• KONNO Shyu

  The Department of Neurology, School of Medicine, Iwate Medical University

• YAMAZAKI Etsuko

  The Department of Neurology, School of Medicine, Iwate Medical University

• KUDOH Masako

  The Department of Neurology, School of Medicine, Iwate Medical University

• TOHGI Hideo

  The Department of Neurology, School of Medicine, Iwate Medical University

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