Clinical Significance of Antiheart Antibodies after Myocardial Infarction.

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概要

• 論文の詳細を見る

• We used one-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis of myocardial proteins followed by Western blotting to study the formation of antiheart antibodies during three months after myocardial infarction and the relationship between the appearance of antibodies and clinical and laboratory findings. Fifty-four percent of the 66 patients with infarction had different types of antiheart antibodies. The autoantibodies detected most frequently were against 35 and 42 kDa cardiac proteins. Immunoblottings with purified proteins showed that these autoantibodies reacted against myocardial tropomyosin and actin, which have been detected after acute myocardial infarction and can have immunogenetic activity through a humoral immune response. However, only the presence of autoantibody against myocardial tropomyosin correlated significantly with the presence of clinical and laboratory findings. Our results suggest that autoantibody against myocardial tropomyosin may play an immunopathogenic role in the development of symptoms in these patients.

• International Heart Journal刊行会の論文

著者

• ARANEGA Antonia

  Basic Cardiovascular Research Section, Department of Morphological Sciences, School of Medicine, Uni

• PRADOS Jose

  Department of Health Sciences, University of Almeria

• Aranega Amelia

  Basic Cardiovascular Research Section Department Of Morphological Sciences School Of Medicine Univer

• Melguizo Consolacion

  Department Of Health Sciences University Of Almeria

• ARÁNEGA Antonia

  Basic Cardiovascular Research Section, Department of Morphological Sciences, School of Medicine, University of Granada

• VELEZ Celia

  Basic Cardiovascular Research Section, Department of Morphological Sciences, School of Medicine, University of Granada

• MARCHAL Juan

  Basic Cardiovascular Research Section, Department of Morphological Sciences, School of Medicine, University of Granada

• PRADOS Jose

  Department of Health Sciences and Clinical Psychology, University of Almeria

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• Clinical Significance of Antiheart Antibodies after Myocardial Infarction.

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