Beneficial Effects of Testosterone Undecanoate on the Lipoprotein Profiles in Healthy Elderly Men. A Placebo Controlled Study.:A Placebo Controlled Study

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概要

• 論文の詳細を見る

• Background and Methods. In order to assess the effects of testosterone undecanoate (TU; 120mg/d orally for 2 months) on serum lipid, lipoprotein, and apolipoprotein levels in healthy elderly men, the placebo (PL) controlled study was performed on 37 elderly men, aged between 53 and 89 years. In all subjects venous blood samples were taken after an overnight (10 hours) fast and sera were stored -70°C until analysis. Results. In PL group, neither hormonal data nor lipid, lipoprotein, and apolipoprotein levels showed significant changes. After TU supplementation, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and estradiol (E2) levels decreased from 198±30.7mg/dl to 174±41.9mg/dl (p<0.05), from 111±18.14mg/dl to 87.9±29.4mg/dl (p<0.01), and from 862±16.9pmol/l to 70.5±18pmol/l (p<0.01), respectively. Statistically significant differences were not observed in the serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein (apo) A-1 and apo B levels after TU treatment. The mean ratios TC/HDL-C and LDL-C/HDL-C as coronary risk factor criteria decreased significantly in the TU but not in the PL group. No obvious side effect was observed in those who took TU except for reported pyrosis in 2 of 17 elderly men. Conclusions. These data indicate that the increased serum levels of total testosterone (TT) produced by administration of TU, 120mg/d orally for 2 months lead to supressed levels of TC and LDL-C and E2 but not significantly changed levels of TG, HDL-C, apo A-1 and apo B. Thus, we conclude that TU may be an effective drug for protecting coronary heart disease in healthy elderly men with lowered TT and FT levels. It may also have beneficial effects for sexual function and behavior.

• International Heart Journal刊行会の論文

著者

• Ari Zeki

  Department Of Biochemistry School Of Medicine University Of Celal Bayar

• YIGITOGLU M.

  Department of Biochemistry University of Celal Bayar

• UYANIK Bekir

  Department of Biochemistry University of Celal Bayar

• GÜMÜS Bilali

  Department of Urology, University of Celal Bayar

• ARSLAN Taciser

  Department of Biochemistry University of Celal Bayar

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