Coronary Microvascular Dysfunction is Associated with Ischemic-like Electrocardiogram during Exercise in Patients with Anginal Chest Pain and Normal Coronary Angiograms
スポンサーリンク
概要
- 論文の詳細を見る
To determine the possible mechanism of the ischemic-like electrocardiogram (ECG) during exercise in the presence of anginal chest pain and normal coronary angiograms, both a treadmill exercise test (TET) and coronary hemodynamic study were prospectively performed in 33 consecutive patients (18 females and 15 males, aged 48±10 years) with angina of unknown cause. Although baseline characteristics and coronary hemodynamics were similar between patients with (TET+, n=17) and those without (TET-, n=16) ischemic-like ECG during TET, effort angina was more frequently seen in the former group (p<0.01). Compared to TET-patients, TET+patients had a significantly lower maximum great cardiac vein flow (GCVF, 108.8±47.0 vs 146.4±23.4ml/min, p=0.007), higher minimum coronary vascular resistance (0.94±0.41 vs 0.61±0.09mmHg/ml/min., p=0.003), and lower corrected GCVF (GCVF/rate-pressure product, 0.0087±0.0036 vs 0.0125±0.0019, p=0.001) after dipyridamole infusion (0.56mg/kg for 4min.). Though coronary flow reserve was significantly lower in TET+than in TET-patients (2.26±0.59 vs 3.08±0.48, p=0.0001), myocardial oxygen consumption and myocardial efficiency (rate-pressure product/myocardial oxygen consumption) were still similar between these two groups after dipyridamole infusion. Thus, coronary microvascular dysfunction rather than altered cardiac metabolism could contribute to effort angina and ischemic-like ECG during exercise in patients with anginal chest pain and normal coronary angiograms.
- International Heart Journal刊行会の論文
著者
-
Chen Jaw-wen
Division Of Cardiology Department Of Internal Medicine Taipei Veterans General Hospital
-
TING Chih-Tai
National Yang-Ming University, School of Medicine
-
CHEN Ching-Iuan
Division of Cardiology, Department of Medicine, Veterans General Hospital
-
MAR Guang-Yuan
Division of Cardiology, Department of Medicine, Veterans General Hospital
-
HSU Nai-Wei
Division of Cardiology, Department of Medicine, Veterans General Hospital
-
WANG Shih-Pu
Division of Cardiology, Department of Medicine, Veterans General Hospital
-
CHANG Mau-Song
Division of Cardiology, Department of Medicine, Veterans General Hospital
-
CHANG Mau-Song
Division of Cardiology, Department of Internal Medicine, Veterans General Hospital-Kaohsiung and Taipei
-
MAR Guang-Yuan
Division of Cardiology, Department of Internal Medicine, Veterans General Hospital-Taipei and National Yang-Ming University School of Medicine, Taipei, Taiwan
-
HSU Nai-Wei
Division of Cardiology, Department of Internal Medicine, Veterans General Hospital-Taipei and National Yang-Ming University School of Medicine, Taipei, Taiwan
-
WANG Shih-Pu
Division of Cardiology, Department of Internal Medicine, Veterans General Hospital and the National Yang Ming Medical College
-
Ting Chih-Tai
National Yang-Ming University
-
CHANG Mau-Song
Division of Cardiology, Department of Internal Medicine, Veterans General Hospital and the National Yang Ming Medical College
関連論文
- Combination of an ACE Inhibitor and Indapamide Improves Blood Pressure Control, but Attenuates the Beneficial Effects of ACE Inhibition on Plasma Adiponectin in Patients With Essential Hypertension
- 1 Baseline Serum Matrix Metalloproteinase-9 Level Predicts the Long-Term Prognosis of Different Coronary Revascularizations(Asian Pacific Society of Cardiology Poster Session 2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- A Randomized, Double-blind, Placebo-controlled, 8-week Study to Evaluate the Efficacy and Safety of Once Daily Atorvastatin (10 mg) in Patients with Elevated LDL-cholesterol
- Coronary Microvascular Dysfunction is Associated with Ischemic-like Electrocardiogram during Exercise in Patients with Anginal Chest Pain and Normal Coronary Angiograms
- 1 Mechanistic Link between Endothelial Progenitor Cells and Impairment of Ischemia-induced Neovascularization in Matrix Metalloproteinase 9-deficient Mice(Asian Pacific Society of Cardiology,Poster Session 2(APSC2),Poster Session(English),The 72nd Annual
- Early Alteration of Coronary Hemodynamics in Late Restenosis after Coronary Angioplasty
- Atrial Pacing-Induced Reverse Alternating Wenckebach Periods : A Common Electrophysiologic Phenomenon in Patients with Dual Atrioventricular Nodal Pathways
- Decreased circulating endothelial progenitor cell levels and function in essential hypertensive patients with electrocardiographic left ventricular hypertrophy
- Angiotensin-Receptor Blockers and Risk of Alzheimer’s Disease in Hypertension Population : – A Nationwide Cohort Study –
- Detection of Acute Myocardial Infarction by Evaluation of Ultrasonic Gray Levels in Dogs.
- Increased Risk of Gastrointestinal Malignancy in Patients with Diabetes Mellitus and Correlations with Anti-Diabetes Drugs: A Nationwide Population-based Study in Taiwan
- Increased Risk of Ischemic Stroke in Patients with Systemic Lupus Erythematosus: A Nationwide Population-based Study
- Usefulness of echocardiography in the prediction of early results of catheter balloon mitral valvuloplasty.
- The Effects of Accumulated Experience on Radiofrequency Ablation of Accessory Pathways.
- Safety and Efficacy of a Modified Catheter-Mediated Ablation of Accessory Pathways.
- Reappraisal of Intermediate-Term Follow-Up of Radiofrequency Ablation of Accessory Atrioventricular Pathways for Treatment of Wolff-Parkinson-White Syndrome.
- A Comparative Study of a Modified Catheter-Mediated Direct Current and Radiofrequency Ablation on Atrioventricular Junction.
- Accessory Atrioventricular Pathways and Atrioventricular Nodal Reentrant Tachycardia in Teenagers. Electrophysiologic Characteristics and Radiofrequency Catheter Ablation.:Electrophysiologic Characteristics and Radiofrequency Catheter Ablation
- Effective Renal Plasma Flow Response and Atrial Natriuretic Peptide in Patients with Uncomplicated Acute Myocardial Infarction.
- Quantitative analysis of high-frequency components of signal-averaged QRS complex in chinese patients with acute myocardial infarction. A prospective study for prediction of ventricular tachycardia.:A Prospective Study for Prediction of Ventricular Tachyc
- Association of Tamoxifen Use and Reduced Cardiovascular Events Among Asian Females With Breast Cancer
- Coronary Flow Reserve and Ischemic-like Electrocardiogram in Patients with Symptomatic Mitral Valve Prolapse.
- Artifact Simulating Ventricular and Atrial Arrhythmia.
- Angiotensin-Receptor Blockers and Risk of Alzheimer's Disease in Hypertension Population : A Nationwide Cohort Study