The Heart Sodium Channel Phenotype for Inactivation and Lidocaine Block

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概要

• 論文の詳細を見る

• The heart Na channel, although resembling other voltage-gated Na channels, has important functional and structural differences. For heart channels expressed in oocytcs, the midpoint of the inactivation relationship was 13mV negative to that of rat skeletal muscle Na channels, and sensitivity to tonic lidocaine block was approximately 5 times more sensitive for heart. Co-expression with the β subunit increased the difference in inactivation midpoint to 24mV, largely by changing the midpoint of the rat skeletal muscle channel by 10mV in the positive direction. Co-expression with β1 decreased lidocaine sensitivity for heart but not for skeletal muscle Na channels, and decreased but did not eliminate the greater heart sensitivity to lidocaine block. The differences in inactivation are likely to account for some, but not all, of the differences in lidocaine sensitivity. This cardiac phenotype is important for the role the channel plays in cardiac physiology and pathophysiology, and also may lead to elucidation of structure-function relationships

• International Heart Journal刊行会の論文

著者

• Makielski Jonathan

  Department Of Medicine Section Of Cardiology University Of Wisconsin

関連論文

• Late sodium current is increased in ventricular myocytes from failing human hearts compared with non-failing hearts
• The Heart Sodium Channel Phenotype for Inactivation and Lidocaine Block

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