Identification of Binding Sites for Calcium Channel Antagonists

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概要

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• The binding sites of three typical calcium channel antagonists, 1, 4-dihydropyridines, benzothiazepines and phenylalkylamines, were successfully identified within the primary structures of calcium channels using a photoaffinity labeling technique. The results confirm pharmacological observations of the three antagonists that had been proposed to interact allosterically with each other. We briefly review the results and discuss the future prospects.

• International Heart Journal刊行会の論文

著者

• Nakayama Hitoshi

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Kuniyasu Akihiko

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Nakayama Hitoshi

  Faculty Of Pharmaceutical Sciences Hokkaido University

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