Effect of Two Different Therapeutic Approaches on Total and Cardiovascular Mortality in a Cardiovascular Study in the Elderly (CASTEL).

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Although limited numbers of elderly subjects have occasionally been included in population-based studies, only a few studies have been conducted specifically on elderly hypertensives, and practically none at a population level.We studied 655 hypertensive subjects from a cohort of 2, 254 elderly subjects. The intervention consisted of the creation of a Hypertension Outpatients' Clinic under our auspices but with complete co-operation from general practitioners, randomizing the identified hypertensive patients into pre-established therapeutic drug regimens, and early follow-up recording of mortality for 7 years. The drugs used were clonidine (n=61), nifedipine (n=146) and the fixed combination of atenolol+chlorthalidone (n=144); 304 subjects underwent "free therapy" by their personal physicians without any special intervention. There were 1, 404 normotensive subjects.Overall 7-year follow-up mortality was 34.9% in the hypertensive subjects receiving "free therapy", 22.5% in those receiving "special care", and 24.2% in the normotensives. Cardiovascular mortality was respectively 23.7%, 12.2%, and 12.0%. Overall and cardiovascular annual cumulative mortality were significantly lower in the "special therapy" than in the "free therapy" group. The fixed combination of atenolol and chlorthalidone reduced mortality below that of the normotensives, independent of other cardiovascular risk factors.
International Heart Journal刊行会の論文