The Effects of Thyroid Hormones on the Heart Following Global Ischemia. A Clinical and Experimental Study.:A Clinical and Experimental Study
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概要
- 論文の詳細を見る
Cardiopulmonary bypass is associated with a reduction in plasma thyroid hormone concentrations in patients undergoing cardiac surgery. However, studies of the effects of cardiopulmonary bypass on thyroid function are limited and many studies report conflicting data concerning only the period of cardiopulmonary bypass.In this study, we tried to clinically determine the effects of cardiopulmonary bypass on concentrations of thyroid hormones by comprehensive thyroid function tests in 10 patients before and after surgery, and observed the benefits of triiodothyronine supplementation after global ischemia on myocardial function experimentally in guinea pigs. In patients undergoing surgery, concentrations of total triiodothyronine and free triiodothyronine decreased progressively on the institution of cardiopulmonary bypass and remained below normal levels until 24 hours postoperatively.In the guinea pig hearts studied in a Langendorf perfusion apparatus, T3 supplementation enhanced percentage recovery of ventricular contractile force, heart work and heart rate with respect to other groups receiving no T3 supplementation or T3 supplementation without any ischemic interval.
- International Heart Journal刊行会の論文
著者
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Soncul Halim
Department Of Cardiovascular Surgery Gazi University School Of Medicine
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Ersoz Ali
Department Of Thoracic And Cardiovascular Surgery Gazi University School Of Medicine
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Halit Velit
Department Of Cardiovascular Surgery Gazi University Faculty Of Medicine
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Sinci Volkan
Department Of Cardiovascular Surgery School Of Medicine Gazi University
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Gokgoz Levent
Department Of Cardiovascular Surgery Gazi University Faculty Of Medicine
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Gunaydin Serdar
Department Of Cardiovascular Surgery Gazi University School Of Medicine
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Yener Ali
Department Of Cardiovascular Surgery School Of Medicine Gazi University
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SINCI Volkan
Department of Cardiovascular Surgery, Gazi University, School of Medicine
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SONCUL Halim
Department of Cardiovascular Surgery, Gazi University, School of Medicine
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TATLICAN Oguz
Department of Cardiovascular Surgery, Gazi University, School of Medicine
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BILGEHAN Ayse
Department of Biochemistry, Gazi University, School of Medicine
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GUNAYDIN Serdar
Department of Cardiovascular Surgery, Gazi University, School of Medicine
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HALIT Velit
Department of Cardiovascular Surgery, Gazi University, School of Medicine
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GOKGOZ Levent
Department of Cardiovascular Surgery, Gazi University, School of Medicine
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- The Effects of Thyroid Hormones on the Heart Following Global Ischemia. A Clinical and Experimental Study.:A Clinical and Experimental Study