Indomethacin Treatment in Newborn Canine Endotoxic Shock.

概要

論文の詳細を見る
Prostaglandins have been reported to play an important role in endotoxic shock. However, the beneficial effects of prostaglandin synthesis inhibitors for the treatment of newborn endotoxic shock have been controversial. This study was performed to evaluate the effects of indomethacin on the hemodynamics during fulminant endotoxic shock in newborn dogs. After E. coli lipopolysaccharide (LPS) injection, mean arterial pressure was maintained for the first 60min, and then declined from 53±2 to 27±2mmHg at 120min. Cardiac output dropped from 0.37±0.03 to 0.24±0.03L/min/kg 5min after LPS injection and continued to decline to 0.12±0.01L/min/kg at 120min. Indomethacin treatment 20min prior to LPS injection attenuated the hypotension (50±3mmHg at 120min, p<0.05) and the decrease of cardiac output (0.18±0.02L/min/kg at 120min, p<0.05). Indomethacin treatment 5min after LPS injection also attenuated the hypotension (55±4mmHg at 120min, p<0.05) and the decrease of cardiac output (0.21±0.02L/min/kg at 120min, p<0.05). Survival times were increased by the indomethacin treatments. Thus, indomethacin appears to be beneficial for the treatment of fulminant hemodynamic deterioration in newborn endotoxic shock.
International Heart Journal刊行会の論文