Acute effects of dibutyryl cyclic AMP on renal circulation in congestive heart failure.

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概要

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• Acute effects of dibutyryl cyclic AMP (DBCAMP) on hemodynamics, renal circulation and plasma catecholamine levels were examined in 8 patients with congestive heart failure, NYHA functional class II or III. Before and during intravenous infusion of dibutyryl cyclic AMP at 0.1mg/kg/min for 30min, hemodynamic variables, renal blood flow (RBF) and plasma catecholamine levels were investigated. 1) DBcAMP increased the cardiac index from 2.69±0.65 to 3.60±0.84liter/min/m2 (+33.8%, p<0.001) and heart rate from 70.9±14.3 to 84.1±15.7bpm (+18.6%, p<0.001) and decreased mean aortic pressure from 91.8±11.3 to 82.5±9.8mmHg (-10.1%, p<0.001), and systemic vascular resistance from 1843±570 to 1263±370 dynessec-cm-5 (-31.6%, p<0.001). 2) RBF increased from 335±81 to 517±188ml/min (+54.3%, p<0.05) and renal vascular resistance decreased from 2.33±0.61 to 1.52±0.68×104 dynes-sec-cm-5(-34.5%, p<0.001). 3) Plasma norepinephrine levels increased significantly.The results indicate that DBCAMP is useful for the treatment of congestive heart failure because it improves cardiac hemodynamics by afterload reduction and has a strong vasodilating effect on renal vascular beds.

• International Heart Journal刊行会の論文

著者

• HOSHINO Yumiko

  First Department of Internal Medicine, Niigata University School of Medicine

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• Acute effects of dibutyryl cyclic AMP on renal circulation in congestive heart failure.

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