Does placebo lower blood pressure in hypertensive patients? A noninvasive chronobiological study.:A Noninvasive Chronobiological Study

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概要

• 論文の詳細を見る

• Placebo controlled trials have generally been used in order to evaluate the antihypertensive efficacy of drugs. There is some evidence, though, that blood pressure might not be influenced by placebo. Noninvasive devices for automatic blood pressure monitoring are likely to provide a better assessment of blood pressure response to drugs, as well as to different physiologic and pathologic conditions, than the traditional sphygmomanometric devices. The aim of this study was to investigate the effect of placebo on blood pressure recorded automatically and noninvasively. For this purpose, a chronobiologic approach to the collection, evaluation and interpretation of data seemed most appropriate.A group of 12 patients with a clinical diagnosis of essential hypertension underwent automatic blood pressure monitoring in hospital for 4 days. Measurements were taken every 15 min by an oscillometric instrument with an automatically inflated cuff. After a washout period during which the patients received no treatment, pressure recording was undertaken under basal conditions for 2 days. On the third and fourth days of study, the patients received 2 tablets of placebo, one at 10a.m. and one at 10p.m. In each patient a highly significant circadian rhythm was documented for systolic and diastolic pressure, both under basal conditions and during placebo administration. Blood pressure mesors were higher than reference standards and were not significantly affected by placebo. The circadian amplitudes and acrophases did not differ significantly before and during placebo. Our data indicate that automatically recorded blood pressure is not influenced by placebo.

• International Heart Journal刊行会の論文

著者

• MONTANARI Loris

  Institute of "Clinica Medica", University of Ferrara

• FERSINI Carmelo

  Institute of "Semeiotica Medica", University of Ferrara

• PORTALUPPI Francesco

  Institute of "Clinica Medica", University of Ferrara

• STROZZI Carlo

  Institute of "Clinica Medica", University of Ferrara

• UBERTI Ettore

  Institute of "Clinica Medica", University of Ferrara

• RAMBALDI Riccardo

  Institute of "Clinica Medica", University of Ferrara

• TRASFORINI Giorgio

  Institute of "Clinica Medica", University of Ferrara

• MARGUTTI Angelo

  Institute of "Clinica Medica", University of Ferrara

• PANSINI Raffaele

  Institute of "Clinica Medica", University of Ferrara

• STROZZI Carlo

  Institute of "Clinica Medica", University of Ferrara

• TRASFORINI Giorgio

  Institute of "Clinica Medica", University of Ferrara

• PANSINI Raffaele

  Institute of "Clinica Medica", University of Ferrara

関連論文

• Does placebo lower blood pressure in hypertensive patients? A noninvasive chronobiological study.:A Noninvasive Chronobiological Study
• Sudden Death May Show a Circadian Time of Risk Depending on Its Anatomo-clinical Causes and Age.

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